We use CRISPR/Cas9-based genetic screening methodologies to systematically model the effects of genetic variation associated with risk for neuropsychiatric disorders. We also use these technologies to define the genetic interaction landscape underlying these conditions.
Read moreThe Xenopus tropicalis model system has a proven track-record of relevance to human neurodevelopmental disorders and can be leveraged to assess for higher order phenotypes in a high-throughput manner.
Read moreEx vivo organotypic brain tissue slice cultures are a powerful tool in which to perform perturbation experiments of ASD-relevant genes and assess phenotype in a highly relevant context that most closely relates to in vivo conditions.
Read moreIn vitro iPSC-derived neural progenitor cells and neurons are a key tool for defining the physical and genetic interaction landscapes in the appropriate cellular context for brain disorders.
Read moreThe QBI collaboration, through the Gladstone Institute and the Convergence Zone, is home to a collection of premier mass spectrometers. We specialize in large-scale protein-protein interaction mapping via affinity purification mass spectrometry (AP-MS), with an emphasis on host-pathogen interactions.
Read moreComputational biologists aim to address fundamental and applied questions in biology and biomedicine, by analyzing and modeling biological datasets using sophisticated theoretical and computational techniques.
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