We use CRISPR/Cas9-based genetic screening methodologies to systematically model the effects of genetic variation associated with risk for neuropsychiatric disorders. We also use these technologies to define the genetic interaction landscape underlying these conditions.
Ex vivo organotypic brain tissue slice cultures are a powerful tool in which to perform perturbation experiments of ASD-relevant genes and assess phenotype in a highly relevant context that most closely relates to in vivo conditions.
The QBI collaboration, through the Gladstone Institute and the Convergence Zone, is home to a collection of premier mass spectrometers. We specialize in large-scale protein-protein interaction mapping via affinity purification mass spectrometry (AP-MS), with an emphasis on host-pathogen interactions.
Computational biologists aim to address fundamental and applied questions in biology and biomedicine, by analyzing and modeling biological datasets using sophisticated theoretical and computational techniques.